Lidocaine Versus Amiodarone in Patients With Shockable Out-of-Hospital Cardiac Arrest: A Target Trial Emulation
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The authors aimed to compare the effectiveness of lidocaine versus amiodarone in improving survival and neurologic outcomes in adults with shockable out-of-hospital cardiac arrest (OHCA). Their analysis, utilizing a target trial framework to address confounding factors, found no statistically significant differences in survival to hospital discharge or favorable neurologic outcomes between the two treatments, although the results suggested a potential benefit for lidocaine that could not be ruled out.
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