July 13, 2026 · Prenatal diagnosis · DOI: 10.1002/pd.70215

Genetic Etiology of Miscarriage in a Vietnamese Cohort Using CNV-Seq and Exome Sequencing

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This study investigates the genetic causes of pregnancy loss in a Vietnamese cohort, aiming to characterize the associated clinical features. Analyzing 636 cases, the authors found genetic abnormalities in 32.9% of cases, with numerical chromosomal abnormalities being the most prevalent. The findings suggest that the use of copy number variant sequencing and clinical exome sequencing can aid in identifying genetic factors contributing to pregnancy loss, potentially guiding future pregnancy management.

Minh Doan Thai, Khanh Vu Nguyen, Y-Thanh Lu, Thu-Hang Le Nguyen, Minh Ngoc Phan, Huong Van Pham, Trung Thanh Nguyen, Hoa Thi Phuong Bui, Lan-Anh Thi Luong, Chuong Hong Duong, Sim Thi Nguyen, Son Van Hoang, Mai-Anh Thi Pham, Son Ta Vo, Ngoc-Ha Thi Tran, Thu Huong Nhut Trinh, Thi Minh Thi Ha, Nhat-Thang Tran, Van Thong Nguyen, Quang Thanh Le, Diem-Tuyet Thi Hoang, My-Nhi Ba Nguyen, Yen Nhi Nguyen, Linh Trang Le, Tung Son Nguyen, Thien-Phuc Hoang Nguyen, Dinh-Kiet Truong, Thanh-Thuy Thi Do, Uyen Vu Tran, Duy Minh Phan, Tuong Manh Ho, Hoai-Nghia Nguyen, Hoa Giang, Hung-Sang Tang

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