July 10, 2026 · Pediatric nephrology (Berlin, Germany) · DOI: 10.1007/s00467-026-07466-5

Urothelial protein expression in pediatric patients with ureteropelvic junction obstruction

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The authors aimed to investigate the expression of urothelial proteins in pediatric patients with ureteropelvic junction obstruction (UPJO) and how these proteins are reflected in urine and tissue samples. Their pilot study found significantly higher levels of specific urothelial proteins in the urine of children with UPJO compared to healthy controls, and identified distinct cellular expressions in the obstructed urothelium, suggesting a potential adaptive response to preserve kidney function.

Ashley R Jackson, Sudipti Gupta, Macie Kercsmar, John W Froehlich, Richard S Lee, Brian Becknell, Christina B Ching

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