SMOC2 mediates GLI1+ mesenchymal cell-driven fibrostenosis and predicts postoperative recurrence in Crohn's disease
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The authors investigate the role of GLI1+ mesenchymal cells in the progression of fibrostenosis in Crohn's disease and their potential as therapeutic targets. They find that these cells contribute to fibrosis through the secretion of SMOC2, which promotes extracellular matrix deposition and fibroblast activation. Additionally, high SMOC2 expression correlates with postoperative recurrence, suggesting its utility as a predictive biomarker and a target for treatment.
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