July 8, 2026 · Circulation · DOI: 10.1161/CIR.0000000000001459

Deprescribing in Patients With Cardiovascular Disease Experiencing Polypharmacy: A Scientific Statement From the American Heart Association

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The authors aim to address the challenges of managing polypharmacy in patients with cardiovascular disease by providing guidance on deprescribing strategies applicable across different age groups. They highlight the prevalence and adverse outcomes associated with polypharmacy, emphasizing the need for tailored approaches that involve clinical cues, validated tools, and collaborative decision-making among healthcare teams. This scientific statement seeks to fill the existing gaps in the literature regarding effective deprescribing practices for both cardiovascular and non-cardiovascular medications.

Robert J DiDomenico, Joel C Marrs, Adam P Bress, Quin E Denfeld, Paul P Dobesh, Mark B Effron, Parag Goyal, Chukwuma Onyebeke, Jennifer K Peterson, Mirko Petrovic, American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Quality of Care and Outcomes Research

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