July 6, 2026 · Circulation · DOI: 10.1161/CIRCULATIONAHA.126.079319

Cardiovascular Risk Reduction With GLP-1 RA Drugs

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This paper reviews the cardiovascular risk reduction associated with GLP-1 receptor agonists (RAs), originally developed for type 2 diabetes management. The authors aim to elucidate how these agents not only improve glycemic control but also confer significant cardiovascular benefits, including reductions in major adverse events across various populations. Additionally, the paper discusses the potential of emerging therapies that target multiple incretin pathways to further enhance these cardiovascular outcomes.

Marie Pigeyre, Hertzel C Gerstein

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