June 25, 2026 · Regional anesthesia and pain medicine · DOI: 10.1136/rapm-2026-107773

Analgesic efficacy of locoregional anesthesia techniques in cardiac surgery: a systematic review and network meta-analysis of randomized trials

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The authors aimed to evaluate the analgesic efficacy of various locoregional anesthesia (LRA) techniques in adult patients undergoing cardiac surgery, particularly in terms of opioid consumption, pain scores, and time to first rescue analgesia. Their systematic review and network meta-analysis of 133 randomized trials found that intrathecal opioids provided the most significant reductions in opioid use and pain scores, while erector spinae plane and parasternal intercostal plane blocks showed promise as alternatives. The study highlights the need for further high-quality trials to standardize LRA strategies in cardiac surgery and assess their impact on recovery and safety.

Maxime Dejaegere, Jules Vandepitte, Jef Van den Eynde, Steve Coppens, Wouter Oosterlinck, Steffen Rex, Danny Feike Hoogma

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