June 24, 2026 · Mayo Clinic proceedings · DOI: 10.1016/j.mayocp.2026.06.016

Lumbar Puncture in the 21st Century: an Imaging-Based Primer to Determine Procedural Safety

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The authors aim to address the safety of lumbar puncture (LP) procedures by identifying patients at increased risk for life-threatening complications, particularly in the context of central nervous system mass lesions or altered cerebrospinal fluid dynamics. Through a comprehensive literature review, they propose an imaging-based primer that outlines specific contraindications for LP, integrating these findings with existing clinical guidelines to assist clinicians in decision-making.

Michael J Rigby, Sherri A Braksick, Maximilano A Hawkes

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