Evaluation of the Preclinical and Clinical Obesity Framework for Risk Stratification of Major Adverse Liver Outcomes

The authors aimed to evaluate the association between a newly proposed preclinical and clinical obesity framework and the long-term risk of major adverse liver outcomes (MALO). Their study, which followed over 7 million individuals for an average of 14 years, found that both preclinical and clinical obesity significantly increased the risk of MALO compared to those without excess adiposity, suggesting that this framework could enhance the prediction of liver-related health risks and inform public health strategies.