Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial
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The authors aimed to evaluate the efficacy of the Circadian Rhythm for Mood (CRM) smartphone app in preventing mood episode recurrence in patients with major depressive disorder (MDD) and bipolar disorder (BD). In a randomized clinical trial involving 93 adults, the CRM app significantly reduced the recurrence rate of mood episodes compared to a sham app, suggesting its potential as a digital adjunct to standard care for mood disorders.
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