July 8, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20250198

Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety

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The authors aimed to identify specific brain circuits that can be targeted for stimulation to modify anxiety, utilizing data from patients with brain lesions, TMS, and DBS. Their findings revealed a convergent anxiety circuit, particularly highlighting the right superior frontal gyrus as a potential therapeutic target, and demonstrated that individual connectivity to this circuit correlates with treatment outcomes. This research underscores a novel approach for pinpointing stimulation targets across various neuropsychiatric conditions.

Shan H Siddiqi, Julian Klingbeil, Ryan Webler, Ian H Kratter, Daniel M Blumberger, Michael D Fox, Mark S George, Jordan H Grafman, Alvaro Pascual-Leone, Andrew R Pines, R Mark Richardson, Pratik Talati, Fidel Vila-Rodriguez, Jonathan Downar, Tamara Hershey, Kevin J Black

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