Nerve Growth Factor Gene Delivery via Nanosphere-Hydrogel Composites and Tendon-Bone Interface Healing in a Rat Rotator Cuff Tear Model
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The authors aimed to evaluate the therapeutic efficacy of nerve growth factor (NGF) gene delivery using nanosphere-hydrogel composites for enhancing tendon-bone interface healing in a rat model of acute rotator cuff tears. Their findings demonstrated that NGF-encoding plasmid delivery significantly improved biomechanical strength, bone microarchitecture, and histological repair compared to control groups, suggesting a promising translational approach to improve clinical outcomes in rotator cuff repairs.
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