July 29, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20260003

Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial

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This study aimed to evaluate the effects of oral semaglutide on alcohol craving and consumption in treatment-seeking adults with alcohol use disorder (AUD). While semaglutide did not significantly reduce laboratory-assessed craving, it was associated with a notable decrease in heavy drinking days, drinks per drinking day, and alcohol-related consequences compared to placebo. The results support further investigation into semaglutide as a potential treatment for AUD.

Joseph P Schacht, Joseph T Sakai, Kristen Raymond, Robert Shelton

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