June 23, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.06.032

Associations Between Routine Vaccinations and the Risk of New-Onset Idiopathic Uveitis

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The authors aimed to investigate the relationship between routine vaccinations and the risk of new-onset idiopathic uveitis (NIU). Their retrospective cohort study found that various vaccinations, including those for COVID-19, HPV, and varicella, were associated with a significant reduction in the incidence of NIU within 12 months post-vaccination. These findings suggest a potential protective effect of vaccinations against the development of NIU, highlighting the complex interactions between immune modulation and uveitis.

Matthew J Schulgit, Suraj Bala, Victor Bellanda, Nitesh Mohan, Andrea Arline, David C Kaelber, Phoebe Lin, Danny A Mammo, Sunil K Srivastava, Sumit Sharma

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