June 24, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2503687

A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis

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The authors aimed to evaluate the efficacy and safety of a 6-month treatment regimen for pulmonary rifampicin-resistant tuberculosis compared to the standard 9-month treatment in South Africa. The study found that the 6-month regimen was noninferior in achieving successful treatment outcomes and had a similar safety profile to the standard regimen. This suggests that the shorter treatment duration may be a viable alternative for managing rifampicin-resistant tuberculosis.

Francesca Conradie, Tasnim Badat, Asanda Poswa, Shakira Rajaram, Shaneen Kooverjee, Gary Maartens, Graeme Meintjes, Jennifer Hughes, H Simon Schaaf, Pauline Howell, Norbert Ndjeka, Patrick P J Phillips

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A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis

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