June 17, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2506905

Cefazolin for Methicillin-Susceptible <em>Staphylococcus aureus</em> Bacteremia

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The authors aimed to determine whether cefazolin is noninferior to antistaphylococcal penicillins (flucloxacillin or cloxacillin) in treating methicillin-susceptible *Staphylococcus aureus* bacteremia, particularly regarding 90-day mortality rates. The study found that cefazolin demonstrated noninferiority in mortality outcomes and was associated with a lower incidence of acute kidney injury compared to the penicillin group.

Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group, Todd C Lee, Lauren A Barina, Genevieve Walls, Anna L Goodman, Dafna Yahav, Matthew P Cheng, Marc Bonten, Asha C Bowen, Tom Boyles, Nick Daneman, Miquel B Ekkelenkamp, Nesrin Ghanem-Zoubi, Marjolein P M Hensgens, Nynke G L Jager, Achim J Kaasch, Ilse J E Kouijzer, Roger J Lewis, Thomas Lumley, David C Lye, Emily G McDonald, Genevieve McKew, Alistair R D McLean, Brendan J McMullan, Zoe K McQuilten, Susan C Morpeth, David L Paterson, Jason A Roberts, J Owen Robinson, Hiroki Saito, Matthew Scarborough, Jaap Ten Oever, Rebecca M Turner, Jonas Tverring, Sebastiaan J van Hal, Steve A Webb, Lynda M Whiteway, Cesar A Arias, Andrew Henderson, George S Heriot, Tom L Snelling, Kevin Afra, Shabinah S Ali, Sharon Amit, Nicholas A Anagnostou, Sophia Archuleta, Stephen J Aston, Eugene Athan, Nadav Baharav, Anthony D Bai, Bridget E Barber, Abinayah Baskaran, Michelle M A Berkeley, Emma J Best, Nilesh R Bhilave, Max G Bloomfield, Katherine A Bond, Jennifer Bostock, Carly L Botheras, Mark A Boyd, Sophia M E Bradshaw, Elizabeth J Briggs, Philip N Britton, Anita J Campbell, Beau Z Carr, James A Chancellor, Kevin Chen, Elaine Y Cheong, Ka Lip Chew, Po Ying Chia, Rispah Chomba, Brian S W Chong, Chris J N Clews, Jonathan M Cohen, Robert J Commons, Tim Cutfield, Peter Daley, Diane S Daniel, Jane Davies, Partha De, Justin T Denholm, Mia Di Virgilio, Yael Dishon-Benattar, Ravindra Dotel, Erick H Duan, Nicholas Easom, Noa Eliakim-Raz, Michelle M England, Mark Fahmy, Aidan R Findlater, Katie L Flanagan, Ethan Z J Foo, Hong Foo, Daniel P Forster, Michael Fralick, Jaimie L Frazer, Andrew P Gador-Whyte, Katherine Garnham, Greg J German, Niladri Ghosh, Elisabeth H Gisolf, Stefano G Giulieri, Susan R Goulding, Jennifer M Grant, Daniel Gregson, Kate C Grimwade, Mordechai Grupper, Stephen D Guy, Amanda Gwee, Victoria G Hall, Erica J Hardy, David J Harris, James Hatcher, Mark R Hobbs, Natasha E Holmes, Benjamin P Howden, Paul J Huggan, Zoe A Jennings, Jennie Johnstone, Thomas Juniper, Shirin Kalimuddin, Musaiwale Kamfose, Christopher Kandel, Matthew J Kelly, Robert A Kozak, Michelle Kümin, Francois Lamontagne, Jillian S Y Lau, Ivor Russel Lee, Ray J Lin, Daisy Lindsay, Martin J Llewelyn, Yves Longtin, Sylvain A Lother, Christopher E Luey, Derek R MacFadden, Andrew A Mahony, Catherine Malden, Isabelle Malhamé, Laurens A Manning, Michael Marks, Leslie J Martin, Gail V Matthews, Patrick H McGann, James H McMahon, Alexandra Melon, Vidthiya Menon, Dominik Mertz, Michael P Meyer, James S Molton, Jocelyn M Mora, Ed Moran, Leanne M Mortimer, Satwik Motaganahalli, Matthew P Muller, Alasdair P S Munro, Fionnuala A Murray, Srinivas Murthy, Vanathi Nagendra, Henco Nel, David W J New, Vi Nguyen, Grace Norton, Katherine M Norton, Clare B Nourse, Clemency J S Nye, Kevin O'Callaghan, Matthew V N O'Sullivan, Sean W X Ong, Akaninyene A Otu, Melissa Owen, Jesse Papenburg, Leighanne O Parkes, Mical Paul, Santiago Perez-Patrigeon, Neta Petersiel, Lina Petrella, Sarah L Pett, David Pham, Chiara J Piazzese, Sebastien Poulin, Renata Rehak, Elissa Rennert-May, Alexander J Richards, Benjamin A Rogers, Euna Sahng, Brenda Salada, Oded Scheuerman, Kellie Schneider, Thomas R Schulz, Kevin L Schwartz, Peter A Simos, Harsimran Singh, Fleur S Sinkeler, Simon Smith, Benjamin J Smith, Stephanie W Smith, Ranjani Somayaji, Christine Sommerville, Rima X J Song, David C Sowden, Michael J Stark, Neil R H Stone, Tobias Strunk, Archana Sud, Khine P Swe, Caitlin R Symons, Yen Ee Tan, Thijs Ten Doesschate, Siew Yee Thien, Ashmitha Thomas, Mohamad-Ali Trad, Adrian R Tramontana, Jennifer L Y Tsang, Kimberly Ulett, Jonathan Underwood, Berend J van Welzen, Gloria Vazquez-Grande, Diana C Velasquez Reyes, Janneke D M Verberk, Lesley M Voss, Denise Ward, Rachel H Webb, Timothy J Whitmore, Anat Wieder-Finesod, Heather L Wilson, Evan W Wilson, Hei Man Wong, Kate Wong She, Terence Wuerz, Deborah L Yamamura, Alastair Yeoh, Boris Long Hei Yow, Michael Dymock, Robert K Mahar, Anna McGlothlin, Julie A Marsh, Joshua S Davis, Steven Y C Tong

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