June 15, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2604657

Talquetamab-Daratumumab in Relapsed or Refractory Myeloma

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The authors aimed to evaluate the efficacy of talquetamab in combination with daratumumab and pomalidomide (Tal-DP) compared to daratumumab plus pomalidomide and dexamethasone (DPd) in patients with relapsed or refractory multiple myeloma. The phase 3 trial demonstrated that both Tal-DP and talquetamab plus daratumumab (Tal-D) significantly improved progression-free survival and overall response rates compared to DPd, indicating a promising treatment option for this patient population.

Roberto Mina, Meral Beksac, Paula Rodríguez-Otero, Wenming Chen, María-Victoria Mateos, Jian Li, Philippe Moreau, Yael C Cohen, Chang-Ki Min, Tomas Jelinek, Jing Christine Ye, Hila Magen, Samuel M Rubinstein, Weijun Fu, Vania Hungria, Guldane Cengiz Seval, Joao Samuel Farias, Jakub Radocha, Senem Maral, Mehmet Turgut, Youngil Koh, Daniel O'Leary, Jayr Schmidt Filho, Raymond Thertulien, Gang An, Shang-Yi Huang, Sebastian Grosicki, Agata Tyczyńska, Rahul Banerjee, Matthew J Pianko, Joaquín Martínez-López, Pawel Steckiewicz, Dai Maruyama, Kentaro Fukushima, Albert Oriol, Jordi Lopez Pardo, Hartmut Goldschmidt, Charlotte Pawlyn, Aurore Perrot, Elena Zamagni, Meletios A Dimopoulos, Leo Rasche, Jaszianne Tolbert, William Terry, Christelle Courtoux, Xiao Liu, Sandra Y Vasey, Kaitlyn Connors, Mariacristina Festa, Christoph Heuck, Angélique Langlois, Lisa O'Rourke, Jiangxiu Zhou, Xiang Qin, Jiashen Lu, Joy Gong, Diego Vieyra, Peter M Voorhees, MonumenTAL-3 Investigators

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Talquetamab-Daratumumab in Relapsed or Refractory Myeloma

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