Therapeutic response to anti-VEGF retreatment among eyes with stabilized vision after being lost to follow-up in diabetic macular edema: A nationwide, registry-based cohort study

The authors aimed to investigate the visual and anatomical outcomes of restarting anti-VEGF therapy in patients with diabetic macular edema (DME) who returned with stabilized vision after being lost to follow-up. They found that while a significant proportion of patients with vision decline showed improvement, those with stabilized vision had suboptimal responses, with many not gaining visual acuity despite anatomical improvements. The study suggests that the decision to retreat these patients should be made cautiously, considering the potential need for alternative therapies.