Serum Interleukin-6 Levels in Endometriosis and Endometriosis-Associated Ovarian Cancer: A Systematic Review and Meta-Analysis Demonstrating a Biological Gradient
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This systematic review and meta-analysis aimed to quantify serum interleukin-6 levels across a spectrum from healthy individuals to those with endometriosis and ovarian cancer, assessing the biological gradient of inflammation. The findings revealed a progressive increase in interleukin-6 levels, with levels nearly doubling from endometriosis to ovarian cancer, highlighting the role of inflammation in disease progression. The authors emphasize the need for more prospective studies to further investigate subtype-specific inflammatory responses.
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