June 9, 2026 · JACC. Cardiovascular interventions · DOI: 10.1016/j.jcin.2026.04.026

Comparison of Leaflet Modification Techniques for TAV-in-TAV: Insights From Bench Testing

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The authors aimed to evaluate the leaflet splay geometry produced by different leaflet modification techniques—BASILICA, balloon-assisted BASILICA (BA-BASILICA), and UNICORN—during TAV-in-TAV procedures to mitigate the risk of coronary obstruction. Their bench testing revealed that while BASILICA and BA-BASILICA produced similar vertical leaflet splay areas, UNICORN generated significantly larger functional splay areas under certain conditions, although its feasibility was limited in specific TAV combinations. The study highlights the importance of design, alignment, and implantation depth in optimizing leaflet modification outcomes.

Arif A Khokhar, Alessandro Beneduce, Francesco Tartaglia, Alison Kane, Yusuke Kobari, David Meier, Brooke MacLeod, Gilbert H L Tang, Dariusz Dudek, Jaffar M Khan, Stephanie Sellers, Ole De Backer

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