The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI
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The authors aim to develop a method for localizing the epileptogenic zone (EZ) in patients with medication-resistant epilepsy using dynamic functional connectivity (dFC) measured by fMRI, without the need for simultaneous EEG. They hypothesize that the dFC peak index, which quantifies negative connectivity peaks following interictal discharges, will be elevated in epileptic tissue, particularly in temporal lobe epilepsy (TLE) patients. Their findings support this hypothesis, showing that elevated dFC peak index values correlate with better surgical outcomes, indicating its potential utility in guiding epilepsy surgery.
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