June 11, 2026 · JAMA · DOI: 10.1001/jama.2026.10628

Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial

Listen to this summary

This study aimed to determine whether the administration of sodium bicarbonate during in-hospital cardiac arrest increases the likelihood of patients achieving sustained return of spontaneous circulation. The randomized clinical trial found no significant difference in outcomes between the sodium bicarbonate group and the placebo group, leading to the conclusion that routine use of sodium bicarbonate in this context is not supported. Additionally, the sodium bicarbonate group experienced higher rates of alkalosis and hypernatremia.

Asger Granfeldt, Bertram Lahn Kirkegaard, Mikael Fink Vallentin, Mathias J Holmberg, Nikola Stankovic, Peter Carøe Lind, Anders Gade Kjærgaard, Nanna Houe, Matias Vested, Dan Lou Isbye, Camilla Meno Kristensen, Jesper Kjærgaard, Stine Thorhauge Zwisler, Søren Nygaard Lundsfryd, Louise Breum Petersen, Fredrik Folke, Carolina Malta Hansen, Kasper Karmark Iversen, Morten Schou, Sebastian Wiberg, Signe Juul Riddersholm, Bodil Steen Rasmussen, Kristine Karlsson, Ronni R Plovsing, Christian Svendsen Juhl, Mette Krag, Christian Dalby Sørensen, Peter Kuhne-Qvist, Jakob Oxlund, Christoffer Grant Sølling, Jacob Robsahm Hansen, Lars Peter Kloster Andersen, Jimmi Malmberg Scheel Jensen, Theis Skovsgaard Itenov, Marlene Lauritzen, Malthe Jessen Pedersen, Rasmus Philip Nielsen, Hans Fjeldsøe-Nielsen, Naqibullah Mirzada, Niels Secher, Ulrick Skipper Espelund, Jennifer Rosenkjær Eskol, Kasper Andersen, Anne Craveiro Brøchner, Helene Korvenius Nedergaard, Peter Martin Hansen, Wiebke Henschel, Akil Raad Walli, Michael Sandgaard, Camilla Lundegaard Asferg, Andrei Ciubotariu, Maria Holm Rosenberg Rasmussen, Victor Le Breton, Lykke Kjærgaard Nielsen, Frederik Gautier Hansen, Niklas Brændstrup, Ida Katrine Thomsen, Birthe Sindberg, Lars Wiuff Andersen, Bicarbonate for In-Hospital Cardiac Arrest (BIHCA) Investigators

This is one of 33,000+ journals available on OSLR. Try it free for 14 days.

Free 14-day trial. 33,000+ journals. Cancel anytime.

14-day free trial. No commitment.

"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."

Dr. Jennifer Thompson

Dr. Jennifer Thompson

Portland, OR

Stay current without falling behind

33,000+ journals. 3-minute audio summaries. Free for 14 days.

Download on the App StoreGet it on Google Play