June 15, 2026 · JAMA · DOI: 10.1001/jama.2026.8492

Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes

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The authors aimed to investigate the long-term effects of lifestyle interventions and metformin on the risk of multimorbidity in adults with prediabetes. Their findings revealed that lifestyle interventions significantly reduced the risk of developing multiple chronic conditions compared to placebo, while metformin showed no such benefit. This suggests that lifestyle programs may be more effective in preventing the onset of chronic diseases in this population.

Marcel E Salive, Ashley H Tjaden, Jesse R Ames, Jill P Crandall, Dana Dabelea, Helen P Hazuda, Brandy M Heckman-Stoddard, Peter J Huckfeldt, Shihchen Kuo, Elsa S Strotmeyer, Marinella Temprosa, Elizabeth M Venditti, DPP Research Group

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