Distinct molecular pathways supporting Sjögren's Disease clusters and disease progression

The authors investigate the blood transcriptomic signatures and disease progression in three distinct clusters of Sjögren's disease (SjD): B-cell active with low symptoms (BALS), high systemic activity (HSA), and low systemic activity with high symptoms (LSAHS). They find that both BALS and HSA exhibit significant interferon signaling, with BALS showing a hyperinflammatory state linked to disease progression, while HSA is characterized by pathways promoting proliferation and metabolism. These insights suggest potential mechanisms underlying disease progression in SjD and highlight the importance of distinct molecular pathways in different patient clusters.