Integrated Clinical and Proteomic Profiling of CD19 CAR-T Cell Therapy in Progressive Systemic Sclerosis
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The authors aimed to characterize the clinical, immunologic, and proteomic changes associated with CD19 CAR-T cell therapy in patients with progressive systemic sclerosis. The study found that this therapy resulted in manageable safety profiles and significant clinical improvements, alongside notable changes in plasma proteins related to inflammation and fibrosis. These findings suggest that CAR-T therapy induces broad remodeling of disease-related pathways, warranting further investigation in larger cohorts.
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