Integrated Clinical and Proteomic Profiling of CD19 CAR-T Cell Therapy in Progressive Systemic Sclerosis
Listen to this summary
The authors aimed to characterize the clinical, immunologic, and proteomic changes associated with CD19 CAR-T cell therapy in patients with progressive systemic sclerosis. The study found that this therapy resulted in manageable safety profiles and significant clinical improvements, alongside notable changes in plasma proteins related to inflammation and fibrosis. These findings suggest that CAR-T therapy induces broad remodeling of disease-related pathways, warranting further investigation in larger cohorts.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Arthritis & rheumatology (Hoboken, N.J.)
View all →Jun 11, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Distinct molecular pathways supporting Sjögren's Disease clusters and disease progression
Jun 9, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Development and Validation of the ALARN Model: A Predictive Mortality Score for Antisynthetase Syndrome
Jun 8, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Homocitrullinated Peptides Drive Pro-Inflammatory T-Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis
Jun 4, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Multimodal peripheral blood immunophenotyping and single cell epigenetic analysis of knee osteoarthritis reveals expansion and epigenetic dysregulation of regulatory T-cell and nonclassical monocyte populations
Jun 3, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Fine particulate matter constituents, ozone, and systemic lupus erythematosus: A large general-population cohort analysis with extended quantile g-computation
Jun 1, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart
More in Pediatrics
View all →Sep 23, 2026 · The New England journal of medicine
Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma
Sep 23, 2026 · American journal of respiratory and critical care medicine
Combined results of the TETON-1 and TETON-2 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis
Sep 23, 2026 · American journal of respiratory and critical care medicine
Biologic outcomes in severe asthma patients by smoking status: evidence from SHARP
Sep 23, 2026 · The New England journal of medicine
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis
Sep 23, 2026 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Five-Year Follow-Up of the Phase III ASCOT Trial of Adjuvant S-1 After Resection for Biliary Tract Cancer
Sep 23, 2026 · Pediatric nephrology (Berlin, Germany)
IPNA clinical practice recommendations for the management of aHUS and secondary TMA in children
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
