Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart

The authors aimed to characterize shared and tissue-specific myeloid and stromal cell phenotypes across lung, synovium, skin, and heart to uncover key cellular subtypes involved in pathogenic tissue activation. By analyzing single-cell RNA sequencing data from various tissues, they identified distinct and overlapping cell populations, revealing common pathogenic subsets like SPP1+ macrophages and POSTN+ fibroblasts in diseased states. Their findings enhance the understanding of the roles of myeloid and stromal cells in health and disease, potentially informing future therapeutic strategies.