June 3, 2026 · Arthritis & rheumatology (Hoboken, N.J.) · DOI: 10.1002/art.70234

Fine particulate matter constituents, ozone, and systemic lupus erythematosus: A large general-population cohort analysis with extended quantile g-computation

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The authors aimed to determine the association between exposure to individual fine particulate matter (PM<sub>2.5</sub>) constituents and the onset of systemic lupus erythematosus (SLE), as well as the potential modifying effect of ozone on this relationship. Their analysis of a large cohort revealed that higher levels of PM<sub>2.5</sub>, particularly from mineral dust, were linked to increased SLE risk, with ozone also contributing to this risk, especially in low ozone environments.

Naizhuo Zhao, Sasha Bernatsky, Sharon Dowell, Brittany Banbury, Jeffrey R Curtis, Grace C Wright, Emily E Holladay, Amy Mudano, Cristiano S Moura, Gail S Kerr

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