June 4, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.05.020

The effect of myo-inositol supplementation on gestational diabetes mellitus prevention: a systematic review and meta-analysis

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This systematic review and meta-analysis aimed to evaluate the effectiveness of myo-inositol supplementation in preventing gestational diabetes mellitus (GDM) among women without pre-existing diabetes during pregnancy or the preconception period. The results indicated that myo-inositol significantly reduced the risk of GDM by 44%, while showing no significant impact on secondary maternal and neonatal outcomes. The findings suggest that myo-inositol is a promising and safe preventive strategy for GDM, potentially enhancing maternal metabolic health.

Raquel Poyatos León, Vicente Martínez-Vizcaíno, Irene Sequí Domínguez, Gema Sanabria Martínez, Ana Díez Fernández, José Alberto Martínez Hortelano

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