June 20, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.06.017

International Trends in Concurrent Hysterectomy at Risk-Reducing Surgery in BRCA1/2 pathogenic variant carriers: A mixed-methods study

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This study investigates the international trends and decision-making factors surrounding the execution of concurrent hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 pathogenic variant carriers. The authors found significant regional variations in the practice, with much higher rates in North and South America compared to Europe and Australia, and identified various barriers and facilitators influencing these decisions, including cultural differences and the lack of clear guidelines.

Tamar A Gootzen, Barbara M Norquist, Roni Nitecki Wilke, Bente Hoppenreijs, TUBA WISP Hysterectomy Consortium, Marleen Mhj van Gelder, C Marleen Kets, Michiel Simons, Karen H D Lu, Elizabeth M Swisher, Rosella Pmg Hermens, Miranda P Steenbeek, Joanne A de Hullu

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