June 24, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.06.019

Early life adversity and polycystic ovary syndrome among North American pregnancy planners

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This study investigates the relationship between early life adversities, specifically adverse childhood experiences (ACEs), and the prevalence of polycystic ovary syndrome (PCOS) among North American women planning pregnancy. The authors found that higher exposure to ACEs is significantly associated with an increased likelihood of self-reported PCOS, suggesting that childhood adversities may have long-lasting effects on gynecologic health. These findings highlight the importance of considering early life stressors in understanding the risk factors for PCOS.

Lauren A Wise, Krystal E Kuan, Yael I Nillni, Nyia Noel, Julia C Bond, Sharonda M Lovett, Andrea S Kuriyama, Chanelle J Howe, Kenneth J Rothman, Renée Boynton-Jarrett

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