The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK-dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis
Listen to this summary
The authors investigate the role of the nuclear receptor TR4 in fibroblast activation and its contribution to tissue fibrosis in systemic sclerosis (SSc). They find that TR4 is upregulated in SSc and promotes myofibroblast differentiation through Gα12/ROCK-dependent cytoskeletal remodeling, suggesting that targeting TR4 could be a potential therapeutic strategy for SSc and related fibrotic diseases.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Arthritis & rheumatology (Hoboken, N.J.)
View all →Jun 11, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Distinct molecular pathways supporting Sjögren's Disease clusters and disease progression
Jun 9, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Development and Validation of the ALARN Model: A Predictive Mortality Score for Antisynthetase Syndrome
Jun 8, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Homocitrullinated Peptides Drive Pro-Inflammatory T-Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis
Jun 4, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Multimodal peripheral blood immunophenotyping and single cell epigenetic analysis of knee osteoarthritis reveals expansion and epigenetic dysregulation of regulatory T-cell and nonclassical monocyte populations
Jun 3, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Fine particulate matter constituents, ozone, and systemic lupus erythematosus: A large general-population cohort analysis with extended quantile g-computation
Jun 1, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Integrated Clinical and Proteomic Profiling of CD19 CAR-T Cell Therapy in Progressive Systemic Sclerosis
More in Pediatrics
View all →Jun 25, 2026 · Blood
Combining Quizartinib with intensive chemotherapy in older patients with newly diagnosed AML: results of the UK NCRI AML18 Trial
Jun 25, 2026 · Blood
Translational Regulation of Sf1 Integrates Alternative Splicing and Hematopoietic Stem Cell Fate
Jun 25, 2026 · The American journal of sports medicine
Association of Central Acetabular Osteophytes With Microinstability and Increased Combined Anteversion in Borderline Dysplasia Hips
Jun 25, 2026 · Blood
Galectin-1 Fuels Monocyte Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
Jun 25, 2026 · Blood
NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab
Jun 24, 2026 · Critical care medicine
Ethical Implications of the Slow Code: A Systematic Review of Ethics of Slow Codes in U.S. Hospitals
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
