The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK-dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis
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The authors investigate the role of the nuclear receptor TR4 in fibroblast activation and its contribution to tissue fibrosis in systemic sclerosis (SSc). They find that TR4 is upregulated in SSc and promotes myofibroblast differentiation through Gα12/ROCK-dependent cytoskeletal remodeling, suggesting that targeting TR4 could be a potential therapeutic strategy for SSc and related fibrotic diseases.
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