Quantitative determination of vaginal diamines as a biomarker for vaginal dysbiosis and IVF-ET outcome
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The authors aimed to investigate how controlled ovarian hyperstimulation (COH) affects vaginal microbiota and embryo implantation outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Their findings revealed that COH significantly increased vaginal diamine levels and altered microbiota composition, with diamine concentrations above 9.5 µM correlating with higher rates of vaginal dysbiosis and embryo implantation failure. The study suggests that vaginal diamines may serve as a predictive biomarker for reproductive outcomes in IVF-ET.
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