May 23, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01566-5

Decidualization potential of endometrial mesenchymal stem cells and their role in reproductive health

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This review explores the decidualization potential of endometrial mesenchymal stem cells (eMSCs) and menstrual stem cells (MenSCs) and their critical roles in reproductive health, particularly in embryo implantation and pregnancy maintenance. The authors aim to elucidate how dysfunction in these stem cells is linked to pregnancy complications such as preeclampsia and endometriosis, while also highlighting their potential as diagnostic biomarkers and therapeutic targets in reproductive medicine.

Reyna Peñailillo, Francesca Velarde, Vicente Peragallo-Papic, Ignacio Valenzuela, Mahesh Choolani, Matthew W Kemp, Lara J Monteiro, Sebastian E Illanes

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