Expression of the antibody-drug conjugate targets TROP2, CLDN6, B7-H3, and DLL3 in mesonephric-like adenocarcinoma of the female genital tract
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This study investigates the expression of potential therapeutic targets TROP2, CLDN6, B7-H3, and DLL3 in mesonephric-like adenocarcinoma (MLA) of the female genital tract, aiming to identify candidates for antibody-drug conjugate (ADC) therapies. The results reveal that B7-H3, TROP2, and CLDN6 are consistently expressed in MLA, suggesting their viability as therapeutic targets, while DLL3 shows minimal expression and is unlikely to be useful for treatment. These findings support the clinical exploration of ADCs in this aggressive cancer type.
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