May 6, 2026 · Gynecologic oncology · DOI: 10.1016/j.ygyno.2026.04.008

Lymph node involvement, surgery and adjuvant treatment in primary Endometrioid Ovarian carcinoma PAtients with eaRly-stage Disease (LEOPARD) - a multinational team initiative

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The authors aimed to investigate treatment patterns and the role of lymph node metastasis in early-stage Endometrioid ovarian carcinoma (ENOC) through a comprehensive analysis of a large, multinational cohort. Their findings suggest that lymph node surgery may be safely omitted in patients with pelvic-confined grade 1 tumors, while a systematic approach to lymph node sampling increases detection rates of metastases. This research could inform type-specific treatment strategies to improve outcomes and reduce morbidity in ENOC patients.

Marcel Grube, Bianca Ribeiro de Souza, Andrea Neilson, Anna Tinker, Annette Staebler, Tamara Kuzma, Gregg S Nelson, Cor de Kroon, Tjalling Bosse, Judith R Kroep, Ly-Ann Teo-Fortin, Dimcho Bachvarov, Koen Brummel, Marco de Bruyn, Hans Nijman, Sophia Andres, Fabienne Schochter, Angelina Fink, Malak Moubarak, Florian Heitz, Philipp Harter, Thomas Bartl, Christoph Grimm, Gerda Hofstetter, Michail Sideris, Ranjit Manchanda, Sabine Heublein, Anna Fischer-Straub, Felix K F Kommoss, Anjali Kulkarni, Barbara Vanderhyden, Katharina Knoll, Alain Zeimet, Pauline Wimberger, Theresa Link, Anna Jaeger, Barbara Schmalfeldt, Björn Lampe, Amber Yasmeen, Larry Phouthavongsy, Hans Walter Vollert, Maria Lycke, Constantia Claudia Mateoiu, Julie Irving, Peter Watson, Mark Nachtigal, Manon de Ladurantaye, Emily van de Laar, Marie Plante, Friedrich Kommoss, Aline Talhouk, Martin Koebel, Michael S Anglesio, Stefan Kommoss

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