Real-world monitoring and clinical management of decreased platelet counts in patients with epithelial ovarian cancer who received first-line maintenance niraparib in the ACTIV1ZE study
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The authors aimed to investigate the frequency, onset, resolution, and clinical management of decreased platelet counts (DPCs) in patients with epithelial ovarian cancer receiving first-line maintenance niraparib. They found that DPCs occurred early in treatment, were resolved in the majority of cases, and were typically managed with dose modifications, leading to low treatment discontinuation rates. However, the absence of dose modifications in many patients who discontinued treatment suggests a need for improved clinical management strategies to enhance patient outcomes.
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