May 6, 2026 · Journal of addiction medicine · DOI: 10.1097/ADM.0000000000001709

Methadone and Torsades de Pointes: A Case Series

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This case series investigates the occurrence of significant QT prolongation and Torsades de Pointes (TdP) in three patients receiving methadone for opioid use disorder (OUD). The authors aim to identify patient-specific risk factors and evaluate various management strategies, such as dose adjustments and alternative treatments, to mitigate cardiac risks while maintaining effective OUD treatment. The study highlights the need for careful monitoring and individualized treatment approaches in patients on methadone therapy.

Alyssa Cheng, Bella Kalayilparampil, Stephanie E Stamatis, Srijan Shrestha, Jeanette M Tetrault, Shawn M Cohen

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