April 30, 2026 · JAMA · DOI: 10.1001/jama.2026.4910

Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery: The EMMA-Can Randomized Clinical Trial

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The authors aimed to determine whether adjunctive embolization of the middle meningeal artery (EMMA) reduces the recurrence of chronic subdural hematomas compared to surgical drainage alone. The randomized clinical trial found that EMMA significantly decreased the rate of symptomatic recurrence at 90 days, with only 4.3% of patients in the EMMA group experiencing recurrence compared to 28% in the control group. These results suggest that EMMA may be an effective strategy to improve outcomes for patients undergoing surgery for chronic subdural hematomas.

Jai Jai Shiva Shankar, Susan Alcock, Nima Kashani, Tim Darsaut, Bill Hao Wang, Marlise P Dos Santos, Geneviève Milot, Cian O'Kelly, Michael E Kelly, Daniela Iancu, Adela Cora, Tom Marotta, Brian van Adel, Kislay Kishore, Brian Drake, Howard Lesiuk, Sylvine Carrondo-Cottin, Jeremy Rempel, Uzair Ahmed, Chiraz Chaalala, Joseph Silvaggio, Zul Kaderali, James McEachern, Mohammed Suheel Abdul Salam, Namita Sinha, Roman Marin, Yan Sin Leung, Robert Balshaw, Ian Fleetwood, Depeng Jiang, Bijoy K Menon, Nishita Singh, Frederick A Zeiler, EMMA-Can investigators

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