April 29, 2026 · JAMA · DOI: 10.1001/jama.2026.5006

The Veteran Affairs' Whole Health Approach for Chronic Pain Management: The wHOPE Randomized Clinical Trial

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The study aimed to evaluate the effectiveness of the Veteran Affairs' Whole Health team intervention for managing chronic pain in comparison to cognitive behavioral therapy (CBT) and usual care. Results indicated that the Whole Health approach led to a statistically significant reduction in pain interference scores after 12 months, outperforming both CBT and usual care, while CBT did not show significant advantages over usual care. These findings suggest that the Whole Health model may be a beneficial strategy for chronic pain management in VA patients.

Karen H Seal, Benjamin J Morasco, Aaron M Martin, Kavitha P Reddy, Theresa M Van Iseghem, Rendelle E Bolton, Barbara G Bokhour, Jennifer Murphy, Lauren M Denneson, Denise Esserman, Eugenia Buta, Natalie Purcell, Daniel Bertenthal, Jacob T Painter, Linda R Abadjian, Liliana C Moore, Allan C Chan, Nicole McCamish, Shira Maguen, Thomas C Neylan, Carolyn J Gibson, William C Becker, wHOPE Study Group

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