Sex differences in pharmacological treatment of heart failure: a meta-analysis of randomized trials
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The authors investigate whether there are sex differences in the efficacy of pharmacological treatments for heart failure, given the historical underrepresentation of women in clinical trials. Their meta-analysis of 139 randomized controlled trials, involving over 292,000 patients, reveals no significant differences in treatment efficacy between men and women, suggesting that the lack of female representation is unlikely to have concealed important sex-specific differences. Nonetheless, they emphasize the importance of improving gender balance in future heart failure trials for ethical and societal reasons.
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