April 27, 2026 · JAMA · DOI: 10.1001/jama.2026.4893

Cardiac Resynchronization Therapy: A Review

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This review examines the role of cardiac resynchronization therapy (CRT) in managing heart failure (HF) associated with cardiac dyssynchrony, particularly in patients with left ventricular (LV) systolic dysfunction and left bundle-branch block. The authors highlight the benefits of CRT, including improved LV function, reduced hospitalization rates for HF, and lower mortality compared to standard medical therapy. They emphasize the importance of timely referral for CRT to optimize clinical outcomes in this patient population.

Caique M Ternes, Jitae A Kim, Anirban Basu, Kenneth A Ellenbogen, Mihail G Chelu

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