Histological and immunohistochemical characteristics of superficial peritoneal endometriotic lesions of clinical responders and non-responders to dienogest treatment

The authors aimed to investigate whether there are distinct histological and immunohistochemical characteristics in superficial peritoneal endometriotic lesions that could differentiate clinical responders from non-responders to dienogest treatment, potentially indicating progesterone resistance. Their findings revealed no significant differences in these characteristics between the two groups, suggesting that intrinsic progesterone resistance may not be the primary reason for treatment non-response in women with endometriosis. However, the study noted that the severity of specific symptoms like deep dyspareunia and dyschezia may be influenced by the expression of estrogen and progesterone receptors in the lesions.