The impact of endometrial preparation on pregnancy loss in vitrified-warmed euploid blastocyst transfer cycles: a randomized controlled trial

This randomized controlled trial investigates whether artificial cycle (AC) endometrial preparation increases early pregnancy loss rates in patients undergoing vitrified-warmed euploid blastocyst transfers. The study found that AC preparation was associated with significantly higher early pregnancy loss compared to natural cycles, suggesting that AC may not be the optimal method for endometrial preparation in these cases. The trial was prematurely terminated due to safety concerns, but the results highlight the need for careful consideration of endometrial preparation strategies in fertility treatments.