April 2, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007119

An Examination of Organ Donor Hemodynamic Variation and Warm Ischemic Times Stratified by Functional Thresholds

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The authors aimed to investigate how hemodynamic variations and warm ischemic times (fdWIT) during organ donation after circulatory criteria death are influenced by specific thresholds of blood pressure and oxygen saturation. Their findings indicate that these thresholds are met sequentially, with oxygen saturation criteria being reached before blood pressure criteria, and suggest that the DCC Ischemic Index (DII) may provide a more accurate assessment of ischemic graft injury than fdWIT alone. Ultimately, the study highlights that fdWIT criteria may not adequately reflect the physiological processes leading to graft injury.

Daljeet Chahal, Laura Hornby, Jordan D Bird, Mypinder S Sekhon

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