April 2, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007116

Effects of High-Flow Nasal Cannula and Helmet Continuous Positive Airway Pressure in Acute Hypoxemic Respiratory Failure

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The authors aimed to compare the physiological effects of high-flow nasal cannula (HFNC) and helmet continuous positive airway pressure (CPAP) against conventional oxygen therapy (COT) in patients with acute hypoxemic respiratory failure (AHRF). Their findings indicate that both HFNC and helmet CPAP improved minute ventilation, reduced inspiratory effort, and enhanced oxygenation compared to COT, although the use of 10 cm H2O of PEEP with helmet CPAP did not provide additional benefits and worsened mechanical power.

Silvia Coppola, Mariarosa Pelliccia, Tommaso Pozzi, Giulia Catozzi, Cosmo Rocco, Alessandro Monte, Geraldina Besana, Davide Chiumello

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