Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

The authors investigate whether colorectal neoplasia in primary sclerosing cholangitis-associated ulcerative colitis (PSC-UC) is driven by microbiota-mediated inflammation linked to secondary bile acid loss. Their findings reveal that PSC-UC is associated with increased inflammatory activity and dysplasia compared to UC-only, and that restoring specific microbial functions related to bile acid transformation may be a more effective therapeutic strategy than simply replacing secondary bile acids.