Extrinsic lipids are absorbed and accumulate in colorectal cancer
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The authors aimed to investigate the uptake of extrinsic fatty acids (FAs) in colorectal cancer (CRC) and their impact on lipid metabolism and tumor progression. They found that long-chain polyunsaturated fatty acids, particularly arachidonic acid, accumulate in CRC tumors, especially in right-sided tumors, and that this uptake is linked to cancer cell proliferation. The study suggests that targeting the pathway of FA absorption, along with the microbiome, could offer new therapeutic strategies for CRC.
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