March 23, 2026 · Gut · DOI: 10.1136/gutjnl-2025-337436

Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study

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The authors aim to elucidate how gut microbial ecology and function vary across different stages of liver disease, from healthy controls to hepatocellular carcinoma. Their findings reveal a decline in microbial diversity with disease progression, identifying specific microbial and functional signatures associated with each stage, which could serve as potential non-invasive biomarkers for diagnosis and prognostic assessment in liver diseases.

Jorge F Vázquez-Castellanos, Sang Jun Yoon, Sung-Min Won, Jeroen Raes, Hak Cheol Kwon, Jiyeon Si, Ki Tae Suk

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