Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma
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This study investigates the effects of tumour-autonomous interleukin 6 (IL-6) signalling in intrahepatic cholangiocarcinoma (iCCA), particularly its intracellular and intercellular consequences. The authors demonstrate that chronic IL-6 signalling drives unique transcriptional programs, metabolic vulnerabilities, and immunomodulatory effects, revealing potential therapeutic targets and highlighting the role of IL-6 in shaping both the tumour microenvironment and immune cell interactions.
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