Association of Clonal Hematopoiesis with Incident, Late-Onset, Seropositive Rheumatoid Arthritis

The authors aimed to investigate the association between clonal hematopoiesis (CH) and the risk of developing late-onset, seropositive rheumatoid arthritis (RA). Their findings indicate that CH, particularly DNMT3A-mutated CHIP and certain chromosomal alterations, significantly increase the risk of incident seropositive RA, while no such association was observed for seronegative RA. Additionally, genetically predicted higher levels of complement proteins appeared to modify this association, suggesting a complex interplay between genetic factors and RA susceptibility.